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為了更好地開展國內外學術交流與合作研究，我校長白山生物資源與功能分子教育部重點實驗室特別邀請香港理工大學生物化學工程實驗室姚鐘平教授舉辦“Mass Spectrometry: New Techniques and New Roles”的專題講座。請重點實驗室人員以及相關科技人員踴躍參加。

講座人：姚鐘平 教授

時 間：2012年7月18日下午15：30

地 點：科技樓八樓會議室

延邊大學科技處

二0一二年七月十八日

附：姚鐘平教授簡介

Mass Spectrometry: New Techniques and New Roles

Zhongping Yao

Department of Applied Biology and Chemical Technology

------The Hong Kong Polytechnic University

Mass spectrometry is a rapid and sensitive tool widely used for analysis of various samples. Development of new sampling and ionization techniques has greatly facilitated mass spectrometric analysis and allowed new insight into chemical and biological systems. We have recently developed MALDI-MS-based techniques to enable direct analysis of solid samples and sensitive detection of phosphopeptides. Moreover, we have developed wooden tips and other tips for ESI-MS analysis and further extended these techniques for direct ionization analysis and in vivo studies of plant and animal systems. Details of these techniques and their applications will be presented.

References:

1. Yao, Z. P. Characterization of Proteins by Ambient Mass Spectrometry, Mass Spectrom. Rev. 2012, 31: 437-447.

2. Hu, B.; Lai, Y. H.; So, P. K.; Chen, H. W.; Yao, Z. P. Direct Ionization of Biological Samples for Mass Spectrometric Analysis, Analyst 2012, DOI: 10.1039/c2an16223g.

3. Zhang, S.; Yao, Z. P. Improved Detection of Phosphopeptides by Negative Ion Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Using a Proton Sponge Co-matrix, Anal. Chim. Acta 2012, 711: 77-82.

4. Hu, B.; So, P. K.; Chen, H. W.; Yao, Z. P. Electrospray Ionization Using Wooden Tips, Anal. Chem. 2011, 83: 8201-8207.

So, P. K.; Yao, Z. P. Oil-Assisted Sample Preparation: A Simple Method for Analysis of Solid Samples using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry, Anal. Chem. 2011, 83: 5175-5181.

Education

B.Sc., Fudan University, 1988

M.Sc., Fudan University, 1991

Ph.D., The Hong Kong University of Science and Technology, 2000

Postdoc., University of Maryland at College Park, 2000-2002 (with Prof. Catherine Fenselau)

Postdoc., University of Cambridge, 2002-2005 (with Prof. Carol Robinson FRS)

Discipline

Food Safety and Technology, Cancer Research, Drug Discovery and TCM

? New ionization and sampling techniques of mass spectrometry

? Direct analysis of herbal medicine, food, biological tissue, clinical samples and environmental samples

? In vivo detection of secondary metabolites of plants and animals

? Molecular recognition and protein interactions

? Biomarker discovery and mechanism studies of diseases

責任編輯:陳艷玲